Wade Wilson
Chris Brander
George Lutz
Mark Tobias
Michael Waechter
Richard Messner
Van Wilder
Monty
Will Hayes
Paul Conroy
Frank Allen
Gary / Gavin / Gabriel
Mike Hanson
Mr. D
Kevin
Hannibal King
Hal Jordan / Green Lantern
Mike Connell
Ryan Reynolds
Jonas
Self
Captain Excellent
Andrew Paxton
Guy (voice)
Mitch Planko
Nick Walker
Nolan Booth
Jared (uncredited)
Matt Weston
Self (archive footage)
Turbo (voice)
Young Damian
Jerry Hickfang / Mr. Whiskers (voice) / Bosco (voice) / Deer (voice) / Bunny Monkey (voice)
Matthew
Carver (uncredited)
Bill Pope
Randol Schoenberg
Curtis
Man Killed by Clinch in Bar (uncredited)
Wade Wilson / Deadpool / Juggernaut (voice)
Michael Bryce
Wade Wilson / Deadpool
Rory Adams
Wade Wilson / Deadpool / Nicepool
Male Nurse
Chip
Seth
Narrator (voice)
Narrator
Quigley
Henry Lipschitz
Karl O'Reilly
Ganesh / Jeffrey
Andy
One
Guy
Eteon Director / Victor Locke
Clint Briggs
Cal
Red Shoes
Ben Colson
Kevin Bannister
Dick the Daring
Adam Reed
Detective Pikachu (voice)
Michael 'Berg' Bergen
Self - Guest
Ryan Reynolds (voice)
Billy Simpson
Spence
Ty Cheese (voice)
Macro
Derek Tillman
Self - Host
Overweight Guy (voice)
Paul Nodel
Jay De Boom
Bobby Rupp
Tony Hemingway
Self - Cameo (uncredited)
Self - Narrator (voice)
Weatherman
Self - Guest Host
Himself