Woman in Elevator
Check-In Girl
Opal
Middle-Aged Woman
Cynthia
Kate the Home Health Care Nurse
Nurse Daniels
Unemployment Clerk
Mrs. Battle
Mary
Streetwalker
Twila
Landlady
Kimberly
Janine
Big Customer
Mrs. Hambrick
Agnes Large
Madge Wiggins
Madame Nora
Bank Co-Worker
Rhonda Dooley
Minny Jackson
Ayisha Lebaron
Jenny
Nurse
Tanya
Waitress
Narrator
Loray
Wanda
Dr. Nance
Rochelle
Nurse Keller
Narrator (voice)
Rowena Jeffers
Aunt Honey
Dr. Corman
Angel Angelique
LeSonia Robinson
Johanna Reyes
Self
Papa / Elouisa
(voice)
Mrs. Otterton (voice)
Miss Harris
Linda Workman
Security Guard
Dorothy Vaughan
Roberta Taylor
Kelly Banks
Shawna
Zelda Fuller
Detention Teacher
Roark's Nurse
Nativity Watson
Evelyn
Nurse B
Elegant Guest (as Octavia L. Spencer)
Baby Nurse
Black Belly
Hildy
Nurse #2
Neighbor in Alley
Stylist
Woman
Troubled Woman
Alison
Martha (voice)
Mrs. Barrett
Judy
Dr. Evilini
Harriet Wilson
Sue Ann
Karen
The Manticore (voice)
Grandma
Emily Stanton
Dab-Dab (voice)
Laqueta Mills
Hattie Hayes
Rhonda (segment "Auto Motives")
Voice of Octavia Spencer (voice)
Cheerleader
Jurist
Octavia
Sherry
Ruby Rydell
Cashier
Child Welfare Rep
Gloria
Flight Attendant
Ticket Woman
Constance Grady
Elegant guest
Maria Jones
Professor Janack
Arvina Watkins
Regina Tompkins
Nurse Jackson
Harriet Tubman
Octavia Spencer
Host
Debbie
Poppy Parnell
Felicia (voice)
Self - Guest
Detective Grinchauser
Self - Host
Team Martha
Self - Presenter
Self - Panelist
Officer Rhonda Tomasson
Rapid Air Clerk
Shonteeva (voice)
Poppy Scoville
Madam C. J. Walker